A member of the benzimidazole class of anthelmintic compounds, Fenben (FZ) is a potent inhibitor of gastrointestinal parasites and lungworms. It has also been reported to have anti-cancer activity in animals. FZ interferes with the microtubule network, inhibiting the growth of cancer cells and blocking their ability to access energy from glucose metabolism. It has also been shown to have p53-induced mitochondrial translocation and to inhibit glucose uptake, expression of the GLUT transporters, and hexokinase – an enzyme involved in glycolysis.
Fenben is available in a wide range of tablet formulations, gels and liquids for dogs and cats. It is usually prescribed by a veterinarian. If your pet needs a compounded version of this medication, your vet will work with a licensed pharmacist to create a dosage specifically designed for your pet’s needs.
To evaluate the effects of fenbendazole on radiation response, EMT6 tumor cells were cultured in glass bottles that could be made hypoxic by sealing with rubber gaskets, inserting needles for the influx and efflux of gases, and then incubating in a mixture of 95% nitrogen/5% carbon dioxide, containing 1 ppm oxygen. After treatment with either fenbendazole or vehicle, cultures were sealed, transported to the radiation facility and exposed to graded doses of X-rays. Treatment with fenbendazole did not significantly alter radiation dose-response curves for either aerobic or hypoxic cell cultures.